Aquaporin-3 regulates endosome-to-cytosol transfer via lipid peroxidation for cross presentation
نویسندگان
چکیده
منابع مشابه
Lipid peroxidation causes endosomal antigen release for cross-presentation.
Dendritic cells (DCs) present foreign antigen in major histocompatibility complex (MHC) class I molecules to cytotoxic T cells in a process called cross-presentation. An important step in this process is the release of antigen from the lumen of endosomes into the cytosol, but the mechanism of this step is still unclear. In this study, we show that reactive oxygen species (ROS) produced by the N...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2020
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0238484